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What to act on first
76
variants found
8
pathways outside balanced
The loudest signal is a stress system that switches on fast and resets slowly, paired with a brain that clears dopamine slowly and a brake that engages late. Together they describe someone who feels deeply, focuses intensely and has a hard time coming down.
HPA axis and stress
Elevated
FKBP5 (4 variants, both copies), CRH, CRHR1, NR3C1, NR3C2
How it can show up
Turns on fast and resets slowly. The body stays on alert after the moment has passed, and sleep breaks easily after hard days.
What can support it
Body-based practices, a wind-down routine, consistent sleep, magnesium, adaptogenic herbs.
Dopamine synthesis and clearance
Reduced
COMT, MAOA (both copies), MAOB, DBH
How it can show up
Clears slowly. Deep focus when life is calm, thoughts that loop when it isn't. Caffeine hits harder and lasts longer.
What can support it
Protein-rich meals, daily movement, caffeine limits, mindfulness practice.
GABA
Reduced
GABRA2, GABRE (both copies), GABRB3
How it can show up
The brain's brake engages late. Hard to settle at night, and calm between thoughts takes work.
What can support it
Slow breathing, magnesium, L-theanine, a screen cutoff before bed.
Also worth watching
Dopamine reward and neuroplasticity run reduced. Inflammation, endocannabinoid and social bonding signals run slightly elevated.
Strengths in this wiring
Deep, absorbed focus. Strong recovery when supported. A nervous system that reads people and rooms accurately. This wiring is not a mistake. It is a design.
